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High quality nursing intervention in patients with hypertension and its clinical effect

作者: 李为群;
作者单位: 云南省普洱市中医医院; 665099
摘要: [Objective:To explore the high quality nursing intervention in patients with hypertension and its clinical effect.Methods:100 patients with hypertension were selected.They were randomly divided into the control group and the observation group.Thecontrol group was given routine care.The observation group was given high quality nursing intervention.We compared the nursingeffect of two groups.Results:In the observation group,the treatment and nursing compliance rate,quality of life score,nursingsatisfaction were significantly higher than the control group(P<0.05).Conclusion:The application of high quality nursingintervention in patients with hypertension can effectively improve the patient's clinical symptoms and improve the quality of life ofpatients.]

Portopulmonary hypertension in liver transplant candidates

作者:
作者单位:
摘要: [Pulmonary vascular disorders including portopulmonaryhypertension (PoPHT) are among the commoncomplications of liver disease and are prognostically significant. Survival is very low without medicaltreatment and liver transplantation. With advances inmedical therapy for elevated pulmonary artery pressure(PAP) and liver transplant surgery, survival of patientswith PoPHT and advanced liver disease is significantlyimproved. Because of the prognostic significance ofPoPHT and the limited donor pool, a comprehensivepreoperative cardio-pulmonary assessment is of greatimportance in cirrhotic patients prior to transplantsurgery. Therefore, a detailed transthoracic Dopplerechocardiographic examination must be an essentialcomponent of this evaluation. Patients with mild PoPHTcan safely undergo liver transplant surgery. In cases ofmoderate to severe PoPHT, right heart catheterization(RHC) should be performed. In patients with moderateto severe PoPHT on RHC (mean PAP 35-45 mmHg),vasodilator therapy should be attempted. Livertransplantation should be encouraged in cases thatdemonstrate a positive response. Bridging therapy withspecific pulmonary arterial hypertension treatmentagents should be considered until the transplantsurgery and should be continued during the peri- andpost-operative periods as needed.]

Relationship between HSP70-hom single nucleotide polymorphisms and hypertension

作者: 唐小平;
作者单位: Experiment; Med; Center; Affil; Hosp; Luzhou; Med; Coll
摘要: [<正>Objective To investigate the relationship between HSP70-hom(2437 T/C)single nucleotide polymorphism and hypertension,and to analyze the population distribution of this polymorphism.Methods Samples were collected through epidemiological surveys.The HSP70-hom single nucleotide polymorphisms were detected by the method of polymerase chain reaction-restriction fragment]

Clinical characteristics and outcomes of patients with acute aortic dissection: impact of hypertension

作者: 陈照然;
作者单位: State; Key; Lab; Cardiovasc; Dis; Cardiovasc; Instit; &; Fuwai; Hosp; CAMS; &; PUMC
摘要: [<正>Objective To observe the clinical characteristics and outcomes of patients with acute aortic dissection(AAD)and explore the impact of hypertension.Methods The present study enrolled 1 087 consecutive patients with AAD who were confirmed by computed tomographic scanning in Fuwai Hospital from January 2008 to December 2010.The major endpoints were in-hospital death]

The association between orthostatic hypertension and all-cause mortality in hospitalized elderly persons

作者单位: Department; of; Geriatrics; Rabin; Medical; Center; Beilinson; Hospital; Petach; Tikvah; lsrael; Sackler; Faculty; of; Medicine; Tel; Aviv; University; Israel; Department; of; Internal; Medicine; E; Rabin; Medical; Center; Beilinson; Hospital; Petach; Tikvah; lsrael; Department; of; Epidemiology; and; Preventive; Medicine; Tel; Aviv; University; Israel; Internal; Medicine; Department; and; Hypertension; Unit; Chaim; Sheba; Medical; Center; Tel; Hashomer; lsrael
摘要: []

Transcriptome analysis of blood stasis syndrome in subjects with hypertension

作者单位: Medical; School; of; Jinan; University; Guangzhou; 510632; China
摘要: [为与血壅滞症候群联系并且包含了在 hypertension.MethodsThis 学习探索血壅滞症候群的基因机制的 mRNAs 的 ObjectiveTo 屏幕与 Qi 缺乏, Qi 停滞,冷保留和热保留与高血压和血壅滞病人组织,包括那些;象没有血壅滞和健康个人的高血压的病人一样。人的脐的静脉 endothelial 房间与血壅滞症候群与这些健康个人和病人的 sera 是 co 有教养的。全部的 RNA 从这些房间被提取并且由一个高产量的定序方法(Solexa ) 和数字基因表示估计了。差别在这六个组之中表示了基因用与血联系的整个染色体序列,和 mRNAs 被比较识别的壅滞症候群。在基因使用和基因本体论功能的差别被分析。,显著地充实的基因和他们的小径被决定是网络相互作用,并且编码了蛋白质。基因身份被即时聚合酶链 reactions.ResultsCompared 与在血壅滞组,的 sera 有教养的房间证实在健康个人并且非血壅滞组的 sera 的那些文化显示出 11 和 301 差别,分别地在壅滞相关的基因。作为在血壅滞和健康的组之间不同识别的基因包括了激活抄写因素 4,激活抄写因素 3, DNA 损坏可诱导的抄写因素 3, Tribbles 相当或相同的事物 3, CCAAT/enhancer 有约束力的蛋白质 -- ,并且 6 月 proto-oncogene (6 月) 。小径和蛋白质相互作用网络分析证明这些基因与 endoplasmic 蜂窝胃应力被联系。在有血壅滞和 Qi 缺乏, Qi 停滞,热保留,和冷保留的病人的 sera 有教养的房间与在有另外的类型血壅滞症候群的病人的 sera 有教养的房间相比。比较在 28,28,34 ,和 32 特定的基因的表示显示出差别,在高血压的血壅滞症候群的 respectively.ConclusionThe 致病与 endoplasmic 蜂窝胃应力有关并且包含激活的抄写因素的微分表示 4 ,激活抄写因素 3 ,DNA损坏可诱导的抄写因素 3 , Tribbles 相当或相同的事物 3 , CCAAT/enhancer 有约束力的蛋白质--,�]

von Willebrand factor antigen as a therapeutic target of portal hypertension in cirrhosis

作者单位: 1~(st); Division; of; Internal; Medicine; Medical; School; University; of; Ioannina; Division; of; Gastroenterology; Medical; School; University; of; Ioannina
摘要: [Increased thrombotic potential within the liver sinusoids due to local endothelial production of von Willebrand factor antigen macromolecules could represent an additional therapeutic target of portal hypertension in patients with cirrhosis. In this case, anti-inflammatory and antithrombotic drugs could modulate portal pressure by preventing the formation of intrahepatic platelet-induced microthrombi.]

上海某社区临床高血压人群非药物干预效果分析

作者: 罗铭华;
作者单位: (上海市嘉定区江桥镇社区卫生服务中心,上海,201803);
摘要: [目的 分析上海某社区临床高血压人群非药物干预效果.方法 将204例临床高血压人群随机分为干预组(96例)和对照组(108例),干预组采取健康教育、饮食、运动和心理干预等方式,对照组不予干预.9个月后,观察干预组主要不良生活方式改变情况,比较2组对象干预前后的收缩压、舒张压和高血压病知识知晓情况.结果 干预前2组对象收缩压、舒张压和各项高血压知识知晓情况比较,差异无统计学意义(P>0.05);干预后干预组收缩压[(136±12) mmHg]、舒张压[(84 ±8) mmHg]水平低于干预前[(148±13) mmHg、(95±12) mmHg],差异有统计学意义(P<0.05);干预后干预组收缩压舒张压水平低于对照组[(147±13) mmHg、(91 ±14) mmHg],差异有统计学意义(P<0.05).干预后,干预组各项高血压知识知晓情况(60.4%、81.3%、100%、100%、100%)高于干预前(47.9%、70.8%、83.3%、58.3%、25.0%,P<0.05);干预后干预组各项高血压知识知晓情况高于对照组(42.6%、63.0%、77.8%、57.4%、27.8%,P<0.05).干预后,患者的不良生活方式也有一定程度的改善.结论 非药物干预可以帮助临床高血压人群有效控制血压,改善生活方式,提高生活质量,值得推广.]

Salvianolic acid A attenuates vascular remodeling in a pulmonary arterial hypertension rat model

作者单位: State; Key; Laboratory; of; Bioactive; Substances; and; Functions; of; Natural; Medicines; Beijing; Key; Laboratory; of; Drug; Targets; Identification; and; Drug; Screening; Institute; of; Materia; Medica; Chinese; Academy; of; Medical; Sciences; and; Peking; Union; Medical; College; Beijing; 100050; China
摘要: [瞄准:当前的治疗学的途径在 dysregulated 上有有限效果肺的脉管的改变,它肺的动脉的高血压是特征的(哼) 。在我们检验了 salvianolic 酸 A (SAA ) 是否从繁体中文药提取了的这研究,丹·沈稀释了在一个 PAH 老鼠模型的脉管的改变,并且阐明内在的 mechanisms.Methods:哼被注射 monocrotaline 的单个剂量在老鼠导致(MCT 60 mg/kg, sc ) 。老鼠口头上地与任何一个 SAA 被对待(0.3, 1, 3 mg·; kg ·d) 或积极控制 bosentan (30 mg·;为 4 个星期的 kg ·d) 。Echocardiography 和血液动力学的大小在 d 上被执行 28。然后,心和肺被收获,机关索引和肺的动脉墙厚度被计算,并且生物化学、组织化学的分析被进行。在肺的 apoptotic 和发信号的蛋白质的层次用 immunoblotting.Results 被测量:有 SAA 或 bosentan 的处理有效地改善了改变的导致 MCT 的肺的动脉,肺的血液动力学的畸形和恰好室的收缩压力(RVSP ) 的随后的增加。而且,处理显著地在肺稀释了心肌层, parenchymal 损害和骨胶原免职的导致 MCT 的 hypertrophic 损坏。而且,处理在肺稀释了导致 MCT 的 apoptosis 和纤维变性。处理部分恢复了骨头的导致 MCT 的减小形态基因的蛋白质类型 II 受体(BMPRII ) 和在 lungs.Conclusion 的 phosphorylated Smad1/5:SAA 改善肺的动脉的改变在导致 MCT 哼经由激活 BMPRII-Smad 小径并且禁止 apoptosis 最可能的老鼠。因此, SAA 可以在高风险为病人有治疗学的潜力哼。]

Choriocarcinoma-associated pulmonary thromboembolism and pulmonary hypertension: a case report

作者单位: Departments; of; lPathology; Cardiothoracic; Surgery; Diagnostic; Radiology; The; First; Affiliated; Hospital; of; Nanjing; Medical; University; Nanjing; Jiangsu; 210029; China
摘要: []

A pilot study of microRNAs as a new potential biomarkers for hypertension

作者单位: Department; of; Cardiology; Guangdong; Cardiovascular; Institute; Guangdong; Provincial; Key; Laboratory; of; Coronary; Heart; Disease; Prevention; Guangdong; General; Hospital; Guangdong; Academy; of; Medical; Sciences; Guangzhou; 510080; China
摘要: []

顽固性高血压的器械治疗

作者: 王恺皞;
作者单位: (中国医学科学院 阜外心血管病医院,北京,100037);
摘要: [尽管抗高血压药物快速进展,仍然有部分高血压患者的血压经规范的降压治疗无法达标,成为临床上棘手的难治性高血压.近年来,基于器械的降压治疗方法开始被重视,现对各种类型正在研发的可能有潜在临床应用价值的用于治疗难治性高血压的器械做一综述.]

Proteomic identification of differentially expressed proteins in blood exosomes of patients with hypertension

作者:
作者单位:
摘要: [AIM:To analyze the proteins included in exosomes derived from blood of patients with hypertension and seek the main pathologi -cal changes in hypertension .METHODS:Forty-seven patients and healthy subjects were recruited and divided into two comparisons :healthy subjects vs atherosclerosis ( HS vs AS) , and atherosclerosis vs hypertension plus atherosclerosis ( AS vs HT+AS) .We extrac-ted exosomes from blood and utilized LC-MS/MS to identify the protein expression .We used GO analysis to established the hierarchy programs of biological process and molecular function .PPI was used to find the proteins related to the terms .RESULTS:It was found that three final child terms repeatedly shown in BP of the two categories ( HS vs AS and AS vs HT+AS):“signal transduction in re-sponse to DNA damage”,“response to zinc ion”, and“platelet aggregation”.It was found that two final child terms in MF of the two categories:“interleukin 2 receptor binding” and“ploy(A) RNA binding”.The proteins, PSMA6, PSMA7 and CA2, were related to the terms in the two categories .CONCLUSION: We discovered that the exosome proteins may indicate the pathological changes in hypertension through the biological processes related with the specific proteins .These specific proteins, such as VCL, PSMA6, DP, AKAP, ATP5B and CA2, can be the new indicators for severity of hypertension and new therapeutic targets .]
关键词:

Pulmonary hypertension in patients with chronic obstructive pulmonary disease:clinical characteristics and risk factors

作者: 王同生;
作者单位: Dept; Respir; Dis; 1st; Affil; Hosp; Henan; Univ; Sci; Technol
摘要: [<正>Objective To investigate the clinical characteristics of pulmonary hypertension(PH)in patients with chronic obstructive pulmonary disease(COPD)and study the related risk factors.Methods Patients with stable COPD were enrolled in this study,undergoing examinations including full pulmonary function tests(PFT),6-minute]
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